ORM1 MEDIATES OSTEOBLAST/OSTEOCLAST CROSSTALK IN ADOLESCENT IDIOPATHIC SCOLIOSIS VIA RANKL/OPG RATIO ALTERATION

ORM1 mediates osteoblast/osteoclast crosstalk in adolescent idiopathic scoliosis via RANKL/OPG ratio alteration

Adolescent idiopathic scoliosis (AIS), a complex early-onset three-dimensional spinal deformity, remains etiologically ambiguous despite extensive ongoing investigations.Currently, braces and surgeries are primary treatments of AIS, which come with inherent risks and costs.Therefore, there is an urgent need for biotherapeutic targets for AIS.Using

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The phosphatidylglycerol phosphate synthase PgsA utilizes a trifurcated amphipathic cavity for catalysis at the membrane-cytosol interface

Phosphatidylglycerol is a crucial phospholipid found ubiquitously in biological membranes of prokaryotic and eukaryotic cells.The phosphatidylglycerol phosphate (PGP) synthase (PgsA), a membrane-embedded enzyme, catalyzes the primary reaction of phosphatidylglycerol biosynthesis.Mutations in pgsA frequently correlate with daptomycin resistance in S

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Effect of Inoculum Age, Carbon and Nitrogen Sources on the Production of Lipase by Candida Cylindracea 2031 in Batch Fermentation

Production of extracellular lipase by Candida cylindracea DSMZ 2031 was studied in a seven liters batch bioreactor, using palm oil Nesting Equipment (PO), palmitic acid (PA), lauric acid (LA), olive oil (OO) and cooking oil (CO) as carbon source.The effect of carbon and nitrogen sources were studied by measuring the lipase activity.The maximum lipa

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